11 de julho de 2026

Cardiac amyloidosis is a classic example of an infiltrativedisease whose predominant phenotype is characterized by ahypertrophic pattern of myocardial involvement.¹,² The mostrelevant studies—both those focused on the development ofdisease-modifying therapies and cohorts evaluating diagnostictools—have used increased ventricular wall thickness as akey criterion for suspecting cardiac amyloidosis.1-6 Based onthis concept, several diagnostic algorithms have proposedventricular wall […]

Background The diagnosis of cardiac amyloidosis (CA) ischallenging owing to vague symptomatology and nonspecific echocardiographic findings.Objective To describe regional patterns in longitudinalstrain (LS) using two-dimensional speckle-trackingechocardiography in CA and to test the hypothesis thatregional differences would help differentiate CA fromother causes of increased left ventricular (LV) wallthickness.Methods and results 55 consecutive patients with CAwere compared

Recent-onset cardiomyopathy represents a clinically dynamic and potentially reversible clinical framework of non-ischaemiccardiomyopathy, characterized by high variability in left ventricular (LV) function and arrhythmic risk. This clinical consensusstatement provides a structured diagnostic and therapeutic approach based on two prognostic axes: the potential for LV reverse remodelling (LVRR) and the risk of sudden cardiac death (SCD).

Technetium-99m bone scintigraphy has revolutionized the non-invasive diagnosis oftransthyretin cardiac amyloidosis (ATTR-CM) and markedly increased disease recognition.Although this technique should ideally be applied in patients with a high pre-test probability of ATTR-CM, its use in other clinical settings may reveal incidental pathologicalmyocardial uptake that prompts referral to specialized centers even in the absence of typicalred

Cardiac amyloidosis represents a unique disease process characterized by amyloid fibril deposition within the myocardialextracellular space. Advances in multimodality cardiac imaging enable accurate diagnosis and facilitate prompt initiationof disease-modifying therapies. Furthermore, rapid advances in multimodality imaging have enriched understanding ofthe underlying pathogenesis, enhanced prognostication, and resulted in the development of imaging-based markers thatreflect the amyloid