Non-amyloid specific treatment fortransthyretin cardiac amyloidosis: a clinicalconsensus statement of the ESC HeartFailure Association

Pablo Garcia-Pavia 1,2,3,
*†
, Esther Gonzalez-Lopez1,2,†
, Lisa J. Anderson4
,
Francesco Cappelli5
, Thibaud Damy 6
, Marianna Fontana7
,
Jose Gonzalez-Costello8,9
, Ruxandra Jurcut 10,11, Olivier Lairez12,
Peter van der Meer 13, Marco Merlo 14,15, Stefano Perlini16,
and Antoni Bayes-Genis 2,17,18,
*
1
Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, GUARD-HEART ERN, Manuel de Falla, 2, Madrid 28222, Spain; 2
CIBER Cardiovascular,
Instituto de Salud Carlos III, Madrid, Spain; 3
Centro Nacional de Investigaciones Cardiovasculares (CNIC), C. de Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain; 4
Cardiology Clinical Academic Group, St George’s Hospital, London, United Kingdom; 5
Tuscan Regional Amyloidosis Centre, Careggi University Hospital, Florence, Italy; 6
Referral Center
for Cardiac Amyloidosis and Department of Cardiology, APHP CHU Henri Mondor Créteil and Réseau Amylose and Filière Cardiogen, GUARD-HEART ERN, Paris, France; 7
National
Amyloidosis Centre, UCL, Division of Medicine, Royal Free Hospital, London, UK; 8
Department of Cardiology, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain; 9
Bio-Heart, Instituto de Investigación Biomédica de Bellvitge, Barcelona, Spain; 10University of Medicine and Pharmacy ‘Carol Davila’, Bucharest, Romania; 11Expert Center for Rare
Cardiovascular Diseases, Emergency Institute for Cardiovascular Diseases ‘Prof.dr.C.C.Iliescu’, GUARD-HEART ERN, Bucharest, Romania; 12Toulouse University, HealthAge University
Hospital Institute, Toulouse, France; 13Experimental Cardiology University Medical Center Groningen, The Netherlands; 14Cardiothoracovascular Department, Azienda Sanitaria
Universitaria Giuliano Isontina (ASUGI), GUARD-HEART ERN, Trieste, Italy; 15Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria
Universitaria Giuliano-Isontina (ASUGI), University of Trieste, Trieste, Italy; 16Department of Internal Medicine, Emergency Medicine and Amyloidosis Research and Treatment Center,
IRCCS Policlinico San Matteo Foundation, Università degli Studi, Pavia, Italy; 17l’Institut del Cor. Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain; and 18Department of
Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
Received 14 April 2025; revised 23 June 2025; accepted 1 September 2025